2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-147192
    (S,R,S)-AHPC-O-PEG1-propargyl 2098799-79-0
    (S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC. (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (S,R,S)-AHPC-O-PEG1-propargyl
  • HY-W584513
    Thalidomide-NH-(CH2)2-NH-Boc 1957235-57-2
    Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
    Thalidomide-NH-(CH2)2-NH-Boc
  • HY-131886
    Pomalidomide 4'-alkylC4-acid 2225940-48-5 98.04%
    Pomalidomide 4'-alkylC4-acid (linker16) is a E3 Ligase Ligand-Linker Conjugate. Pomalidomide 4'-alkylC4-acid can be used for conjugation to a target protein ligand.
    Pomalidomide 4'-alkylC4-acid
  • HY-170356
    E3 Ligase Ligand-linker Conjugate 151
    E3 Ligase Ligand-linker Conjugate 151 is a conjugate of the E3 ligase Ligand (HY-170353) and linker (HY-W895794). E3 Ligase Ligand-linker Conjugate 151 can be used to synthesize PROTAC SMARCA2/4 degrader-36 (HY-170347).
    E3 Ligase Ligand-linker Conjugate 151
  • HY-162200
    E3 Ligase Ligand-linker Conjugate 47
    E3 Ligase Ligand-linker Conjugate 47 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 47 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 47
  • HY-163217
    PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc
    PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc
  • HY-131717A
    Thalidomide-NH-CH2-COOH TFA 2377032-39-6
    Thalidomide-NH-CH2-COOH TFA is a ligand-linker conjugate for the E3 ligase Cereblon (CRBN). Thalidomide-NH-CH2-COOH TFA can be conjugated to multi-targeted kinase inhibitors to transform them into selective degraders.
    Thalidomide-NH-CH2-COOH TFA
  • HY-169050
    Thalidomide-piperidine 2924858-38-6
    Thalidomide-piperidine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-piperidine can be used to synthesize SMART1 (HY-W998345).
    Thalidomide-piperidine
  • HY-131190
    N-Boc-SBP-0636457-O-C3-COOH 2450350-91-9
    N-Boc-SBP-0636457-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates IAP ligand and a linker. N-Boc-SBP-0636457-OH can be used to design a PROTAC Bcl-xL degrader-1 (HY-131188).
    N-Boc-SBP-0636457-O-C3-COOH
  • HY-169990
    E3 Ligase Ligand-linker Conjugate 142 2704621-78-1
    E3 Ligase Ligand-linker Conjugate 142 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of CFT8634 (HY-145925B).
    E3 Ligase Ligand-linker Conjugate 142
  • HY-163233
    Phthalimidinoglutarimide-5-piperazine
    Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    Phthalimidinoglutarimide-5-piperazine
  • HY-172218
    Lenalidomide-hex-5-ynoic acid 2379870-47-8
    Lenalidomide-hex-5-ynoic acid is a conjugate of E3 ligase ligand and linker, and can be used to synthesize PROTACs, such as PROTAC cGAS degrader-1 (HY-172208).
    Lenalidomide-hex-5-ynoic acid
  • HY-44630
    VH 032 amide-alkylC6-acid 2172819-75-7
    VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs.
    VH 032 amide-alkylC6-acid
  • HY-168254
    E3 Ligase Ligand-linker Conjugate 127 2410316-12-8
    E3 Ligase Ligand-linker Conjugate 127 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 127 can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251).
    E3 Ligase Ligand-linker Conjugate 127
  • HY-161194
    (S,R,S)-AHPC-acetyl-azetidine-PIP-boc
    (S,R,S)-AHPC-acetyl-azetidine-PIP-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-azetidine-PIP-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-acetyl-azetidine-PIP-boc
  • HY-168304
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research.
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
  • HY-130711C
    (S,R,S)-AHPC-C3-NH2 dihydrochloride 2564467-25-8
    (S,R,S)-AHPC-C3-NH2 (dihydrochloride) is the dihydrochloride form of (S,R,S)-AHPC-C3-NH2 (HY-130711). (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.
    (S,R,S)-AHPC-C3-NH2 dihydrochloride
  • HY-161497
    Thalidomide-benzylamine-Py-NH2
    Thalidomide-benzylamine-Py-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and the Linker Boc-NHCH2-Ph-Py-NH2 (HY-161496). Thalidomide-benzylamine-Py-NH2 is utilized for synthesis of PROTAC molecule XYD190 (HY-161494).
    Thalidomide-benzylamine-Py-NH2
  • HY-162198
    E3 ligase Ligand-Linker Conjugate 43
    E3 ligase Ligand-Linker Conjugate 43 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 43 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 ligase Ligand-Linker Conjugate 43
  • HY-162185
    E3 Ligase Ligand-linker Conjugate 12
    E3 Ligase Ligand-linker Conjugate 12 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 12 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 12
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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